TOPU BIO Research -Technologies for metabolite biosynthesis-

Biosynthesis of human drug metabolites

We provide P450s and phase II (e.g. UGTs, SULTs and COMT) metabolites of drugs, environmental compounds and several food factors such as polyphenols.

We developed biosynthetic platform using mammalian DME expression systems in yeast.

Would you have any trouble in preparing desire metabolites?
Our technology would help you study on drug metabolism.

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We have developed drug metabolite preparation system using genetically modified yeast cells. Metabolites can be used for analytical standards, structural confirmation and test compounds for evaluation.
We have abundant line-up of recombinant drug metabolizing enzymes in yeast cells such as CYPs, UGTs, SULTs and so on. We also have animal tissue fractions.

・Preparation of glucuronide using the yeast expressing UGT

・Enzymes for metabolite preparation

・Custom metabolite production

・Case studies for metabolite preparation

We want to hear about your questions or concerns.
Please feel free to contact us with the form.

Company profile

Company Name
TOPU BIO Research Co., Ltd.

Office

Imizu Research Center

5180 Kurokawa, Imizu-shi, Toyama 939-0398, Japan

Established

April 1st, 2011

Capital

8,000,000(JPY)

President
Yuki Nagano

Directors

Yasuhisa Asano Ph.D

Toshiyuki Sakaki Ph.D
Miyu Nishikawa DVM Ph.D

Hiroshi Sakai

Yohei Hayashi

Adviser

Toshio Chow Ph.D

Contact TOPU BIO Research

If you have any questions or comments, please feel free to contact us with the form.

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代謝物受託製造の株式会社TOPUバイオ研究所